Spiking Coordination and its Role in Corticocortical Signaling

September 29, 2014
Speaker: Adam Kohn, Associate Professor, Department of Neuroscience, Albert Einstein College of Medicine


Spiking activity in cortex is coordinated on a range of spatial and temporal scales. Numerous studies have shown that external events and internal states can alter coordination. It has been suggested that coordination in a source area influences the efficacy of the signals it provides to downstream areas. To test this possibility, we recorded simultaneously from populations of neurons in the superficial layers of primary visual cortex (V1) of macaque monkeys, and from their downstream targets in the middle layers of V2. We used stimuli that induce different forms of coordination, including robust gamma activity. We find that enhanced V1 coordination increases the probability of V2 spiking. Our results show that the coordination of spiking activity within a cortical area influences its coupling with downstream areas.

Speaker Bio

Adam KohnAdam Kohn's lab investigates how visual information is encoded and processed by populations of cortical neurons, and how this processing is affected by recent stimulus history, or adaptation. Their work thus addresses issues of neural coding, cortical plasticity, corticocortical signaling, and the neuronal basis of visual perception. The lab employs an approach that involves multielectrode recordings in early and midlevel visual areas of anesthetized and awake, behaving macaque monkeys. Computational methods are used to interpret and understand physiological data, and psychophysical methods are employed to relate our findings to human perception. The lab has also begun using optogenetic tools to further understanding of corticocortical signaling in primate cortex.

Hosted by Aurel A. Lazar.

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