Rapid High-Resolution Imaging Methods for Mapping Brain Structure and Function

Feb 6, 2017
11:00am-12:00pm
Location: 233 Mudd
Speaker: Raju Tomer, Assistant Professor, Department of Biological Sciences, Columbia University

Abstract

Development of molecular tools for optical observation and intervention of neuronal activity, and development of tissue clearing methods together are providing unprecedented opportunities for mapping the architecture of neuronal circuits spread across entire nervous systems. To build upon these opportunities, high-speed sub-cellular resolution volumetric imaging methods are needed that facilitate integrated structural and functional mapping of neuronal circuits with both high (wiring-level) resolution and broad (nervous system-wide) perspective. Principles fundamental to the understanding of neural systems (normal and abnormal) can result from such an integrative approach, but while excellent progress has been made, many fundamental challenges and exciting opportunities remain.

In this talk, I will present my past work on the development of novel optical imaging platforms for rapid high-resolution imaging of intact brains and nervous systems in their entirety, computational approaches to analyze the huge amounts of data that result, tissue clearing and genetic labelling approaches, to contribute towards the understanding of the structural and functional architecture of the vertebrate brains. I will conclude with a brief future perspectives on continued interest of my lab in this field.

Hosted by Christine P. Hendon.


500 W. 120th St., Mudd Room 524, New York, NY 10027    212-854-5660               
©2014-2017 Columbia University